Probiotics for the Treatment of Asthma: A Systematic Review and Meta-Analysis of Randomized Trials

Authors

  • Elham Ansari Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Fatemeh Khorasani Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Hamid Ahanchian Child Health Research Centre, University of Queensland, Brisbane, Australia AND Allergy research center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Hamidreza Kianifar Department of Pediatric Gastroenterology, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Maryam Khalesi Department of Pediatric Gastroenterology, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mohammad Ali Kiani Department of Pediatric Gastroenterology, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Seyed Ali Jafari Department of Pediatric Gastroenterology, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract:

Background: Asthma is a growing problem worldwide and the limitations of the current therapy for allergic asthma highlight the need for novel therapeutics. We conducted a systematic review and meta-analysis to find out the role of probiotics in the treatment of Asthma. Materials and Methods:  In this systematic review, a comprehensive search of the major electronic databases was done till October 2017. Clinical trials comparing the effect of probiotics versus placebo on treating asthma were included. Trials focusing on prevention of asthma were not included. A predefined set of outcome measures was assessed. Continuous data were expressed as standardized mean difference with 95% confidence interval (CI). Dichotomous data were expressed as odds ratio with 95% CI. P-value < 0.05 was considered as significant. Results: 11 studies with 2,027 participants were included. Probiotic intake was associated with a significant improvement in pulmonary function test and slight benefits in asthma control test. Probiotics did not reduce asthma exacerbation and wheezing episodes although there was a high degree of heterogeneity in studies. It also has no significant effect on viral respiratory infection in asthmatics and no improvement in quality of life. Probiotic intake improved the following parameters: longer time free from episodes of asthma. Adverse events were not significant. Conclusion: Although trials showed promising effects of probiotics as an additive on therapy on some parameters of asthma, as this evidence was generated from only a few trials with high degree of heterogeneity, routine use of probiotics as an additive on therapy of asthmatic patients cannot be recommended at this time.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

P135: A Systematic Review and Meta-Analysis on Controlled Treatment Trials of Meta-Cognitive Therapy for Anxiety Disorders

To conduct a systematic review and meta-analysis on controlled treatment trials of meta-cognitive therapy (MCT) for anxiety disorders, studies were included if they employed controlled methodology and treated people above 18 years with anxiety disorders. Case studies (with less than 4 cases) and single case designed studies were excluded. A comprehensive literature search identified 15 trials f...

full text

A Systematic Review and Meta-Analysis of Randomized Controlled Trials Comparing the Safety of Dapagliflozin in Type 1 Diabetes Patients

Background and Purpose: The dapagliflozin’s safety profile in insulin-treated adult type-1 diabetes mellites (T1DM) patients remains poorly explored. Therefore, this systematic review and meta-analysis compared the risk of all-cause side effects, study discontinuation of participants due to side effects, urinary tract infection (UTI), diabetic ketoacidosis, and hypoglycemia between dapagliflozi...

full text

The effect of quercetin on stress The Effect of Quercetin on Stress Oxidative Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trialsers; A systematic review and meta-analysis of randomized controlled clinical trials

Background: Quercetin is one of the main flavonoids, overall distributed in plants. The antioxidant capacity of quercetin is several times vitamin E and glutathione. This systematic review and meta‐analysis of randomized controlled trials were performed to determine the effect of quercetin on oxidative stress (OS) markers. Methods: A literature search was conducted in PubMed, ISI Web of Science...

full text

The safety and effectiveness of the current treatment regimen with or without roflumilast in advanced COPD patients: A systematic review and meta-analysis of randomized controlled trials

&nbsp; Background: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease, which reduces the lung function and causes respiratory symptoms over time, and it is primarily associated with shortness of breath, cough and sputum production. Roflumilast, which is a long-acting selective inhibitor, reduces the anti-inflammatory effect of the main symptoms of COPD. The aim of ...

full text

a systematic review and meta-analysis on controlled treatment trials of metacognitive therapy for anxiety disorders

background: to conduct a systematic review and meta-analysis on controlled treatment trials of meta-cognitive therapy for anxiety disorders. materials and methods: studies were included if they employed controlled methodology and treated people above 18 years with anxiety disorders. case studies (with less than 4 cases) and single case designed studies were excluded. a comprehensive literature ...

full text

Probiotics for the Treatment of Atopic Dermatitis in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Objective: Atopic dermatitis (AD) is a prevalent, burdensome, and psychologically important pediatric concern. Probiotics have been suggested as a treatment for AD. Some reports have explored this topic; however, the utility of probiotics for AD remains to be firmly established. Methods: To assess the effects of probiotics on AD in children, the PubMed/Medline, Cochrane Library Scopus, and OVID...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 8  issue 5

pages  11271- 11285

publication date 2020-05-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023